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Upper esophageal sphincter (UES) metrics on high ...
Jul 17, 2020 · Background: The upper esophageal sphincter (UES) reflexively responds to bolus presence within the esophageal lumen, therefore UES metrics can vary in achalasia. Methods: Within consecutive patients undergoing esophageal high-resolution manometry (HRM), 302 patients (58.2±1.0 year, 57% F) with esophageal outflow obstruction were identified, and …Nadir UES-RP can differentiate achalasia subtypes within the esophageal outflow obstruction spectrum, with highest values in type 2 achalasia. This metric likely represents a surrogate marker for esophageal pressurization..
Keyword: pmid:28707402, PMC5690813, doi:10.1111/nmo.13136, P Blais, A Patel, C P Gyawali, Adult, Aged, Esophageal Achalasia / diagnosis*, Esophageal Sphincter, Upper / physiopathology*, Female, Humans, Male, Manometry / methods*, Middle Aged, PubMed Abstract, NIH, NLM, NCBI, National Institutes of Health, National Center for Biotechnology Information, National Library of Medicine, MEDLINE
From: pubmed.ncbi.nlm.nih.gov
Background:
The upper esophageal sphincter (UES) reflexively responds to bolus presence within the esophageal lumen, therefore UES metrics can vary in achalasia.
Methods:
Within consecutive patients undergoing esophageal high-resolution manometry (HRM), 302 patients (58.2±1.0 year, 57% F) with esophageal outflow obstruction were identified, and compared to 16 asymptomatic controls (27.7±0.7 year, 56% F). Esophageal outflow obstruction was segregated into achalasia subtypes 1, 2, and 3, and esophagogastric junction outflow obstruction (EGJOO with intact peristalsis) using Chicago Classification v3.0. UES and lower esophageal sphincter (LES) metrics were compared between esophageal outflow obstruction and normal controls using univariate and multivariate analysis. Linear regression excluded multicollinearity of pressure metrics that demonstrated significant differences across individual subtype comparisons.
Key results:
LES integrated relaxation pressure (IRP) had utility in differentiating achalasia from controls (P<.0001), but no utility in segregating between subtypes (P=.27). In comparison to controls, patients collectively demonstrated univariate differences in UES mean basal pressure, relaxation time to nadir, recovery time, and residual pressure (UES-RP) (P≤.049). UES-RP was highest in type 2 achalasia (P<.0001 compared to other subtypes and controls). In multivariate analysis, only UES-RP retained significance in comparison between each of the subgroups (P≤.02 for each comparison). Intrabolus pressure was highest in type 3 achalasia; this demonstrated significant differences across some but not all subtype comparisons.
Conclusions and inferences:
Nadir UES-RP can
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Upper esophageal sphincter abnormalities on high ...
The incidence rate of type II achalasia was significantly higher in subjects with abnormal UES than those with normal UES (9.77% vs 2.58%, P = 0.01). After pneumatic dilation, LES resting pressure, LES integrated relaxation pressure, and UES residual pressure were significantly decreased (41.91 ± 9.20 vs 26.18 ± 13.08, 38.94 ± 10.28 vs 16.71 ...Impaired relaxation alone is the most common UES abnormality. The incidence of type II achalasia is associated with abnormal UES. Type II achalasia with abnormal UES has a poorer treatment response, which is a potentially prognostic indicator of treatment for this disease..
Keyword: pmid:32149056, PMC7052552, doi:10.12998/wjcc.v8.i4.723, Can-Ze Huang, Zai-Wei Huang, Yu-Ping Chen, PubMed Abstract, NIH, NLM, NCBI, National Institutes of Health, National Center for Biotechnology Information, National Library of Medicine, MEDLINE
From: pubmed.ncbi.nlm.nih.gov
Background:
Little is known about the clinical significance of upper esophageal sphincter (UES) motility disorders and their association with the treatment response of type II achalasia. None of the three versions of the Chicago Classification of Esophageal Motility Disorders has defined UES abnormality metrics or their function. UES abnormalities exist in some patients and indicate a clinically significant problem in patients with achalasia.
Aim:
To demonstrate the manometric differentiation on high-resolution esophageal manometry between subjects with abnormal UES and normal UES, and the association between UES type and the treatment response of type II achalasia.
Methods:
In total, 498 consecutive patients referred for high-resolution esophageal manometry were analyzed retrospectively. The patients were divided into two groups, those with normal and abnormal UES function. UES parameters were analyzed after determining lower esophageal sphincter (LES) function. Patients with type II achalasia underwent pneumatic dilation for treatment. Using mixed model analyses, correlations between abnormal UES and treatment response were calculated among subjects with type II achalasia.
Results:
Of the 498 consecutive patients, 246 (49.40%) were found to have UES abnormalities. Impaired relaxation alone was the most common UES abnormality (52.85%, n = 130). The incidence rate of type II achalasia was significantly higher in subjects with abnormal UES than those with normal UES (9.77% vs 2.58%, P = 0.01). After pneumatic dilation,
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Upper esophageal sphincter during transient lower ...
Feb 18, 2010 · Mid-TLESR, UES contraction response occurred 2 ± 1.3 s (n = 22) and 1 ± 1.5 s (n = 16) after the distal and proximal esophageal liquid reflux, respectively. A UES relaxation response was seen in only 3/51 recumbent TLESRs, and 3/3 times it was associated with an air component of the mixed reflux..
From: www.ncbi.nlm.nih.gov
ALUMINUM ELECTROLYTIC CAPACITORS UES Bi …
UES tan δ Within ±20% of the initial capacitance value 150% or less than the initial specified value Less than or equal to the initial specified value Rated voltage (V) tan δ (MAX.) 6.3 0.24 10 0.20 16 0.16 25 35 0.14 50 0.12 Z–25°C / Z+20°C Z–40°C / Z+20°C Rated voltage (V).
From: www.nichicon.co.jp
Botulinum Toxin Injection for the Treatment of Upper ...
Forty-nine patients (30 female, 19 male; average age, 59 ± 16 years) with UES dysfunction have been treated at our institution with CP BTX injection since 2000. Seventeen of these patients also underwent CP myotomy. Injections of BTX were occasionally repeated after the treatment effect subsided, and the BTX dose varied widely (average, 39 ± ....
From: www.ncbi.nlm.nih.gov
ALUMINUM ELECTROLYTIC CAPACITORS UES Bi …
UES tan δ Within ±20% of the initial capacitance value 150% or less than the initial specified value Less than or equal to the initial specified value Rated voltage (V) tan δ (MAX.) 6.3 0.24 10 0.20 16 0.16 25 35 0.14 50 0.12 Z–25°C / Z+20°C Z–40°C / Z+20°C Rated voltage (V) Impedance ratio ZT / Z20 (MAX.) 6.3 4 8 10 3 6 16 2 4 25 2 ....
From: www.mouser.com
NYC-Manhattan Community District 8--Upper East Side PUMA ...
5.1% ±2.1% Women 15-50 who gave birth during past year. about 10 percent higher than the rate in New York: 4.7% 217,713; about the same as the rate in United States: 5% 3,877,882Census data for NYC-Manhattan Community District 8--Upper East Side PUMA, NY (pop. 216,874), including age, race, sex, income, poverty, marital status, education and more..
From: censusreporter.org
ALUMINUM ELECTROLYTIC CAPACITORS UES Bi …
UES tan δ Within ±20% of the initial capacitance value 150% or less than the initial specified value Less than or equal to the initial specified value Rated voltage (V) tan δ(MAX.) 6.3 0.24 10 0.20 16 0.16 25 35 0.14 50 0.12 Z–25°C / Z+20°C Z–40°C / Z+20°C Rated voltage (V) Impedance ratio.
From: www.mouser.com
Esophageal Sphincter - an overview | ScienceDirect Topics
Among patients and control subjects, 99 and 100%, respectively, of all IPI events, irrespective of a pH drop, were associated with an abrupt increase in UES pressure (34 ± 2 and 27 ± 6 mmHg, respectively). The average percentage of maximum UES pressure increase over pre-reflux values ranged between 66 and 96% (control subjects) and 34 and 122 ....
From: www.sciencedirect.com
32.4.2 UES, Pharyngolaryngeal, and Esophageal Reflexes
The UES is one of the components of the airway protective mechanisms against entry of gastroesophageal refluxate into the aerodigestive tract.24,94 However, since the magnitude of UES pressure is quite variable and it decreases significantly during sleep61 and periods of calmness, it is conceivable that the pressure of gastroesophageal refluxate may overcome the UES if it occurs during periods of low UES pressure. Hence, UES function during GER events has been of interest and the subject of several previous studies. Although some of these studies report an increase in UES pressure following experimental esophageal acidification,60,98,99 others have not observed a similar response59,68 following gastroesophageal acid reflux events. For these reasons, the UES function during gastroesophageal acid reflux events remains incompletely understood. This difficulty also stems from the fact that GER results in both intraluminal pressure increase and/or pH changes. The UES response to intraluminal pressure increase and distention is variable depending on the intensity and nature of the stimulus. Additionally, the UES response to esophageal acidification has been controversial. Differences in recording techniques might have also added to these difficulties. Earlier reports generally used the station pull-through technique for recording the UES pressure, whereas more recent studies utilized a modified sleeve device for this purpose.In 1957, Creamer and Schlegel100 described the contractile response of the UES to balloon distention and water infusion. This contractile response was found by Car and Roman to involve the CP muscle.80 Freiman et al. showed that bilateral cold block of the cervical vagus completely abolished the UES response to HCl infusion and partially blocked its response to balloon distention in dogs.98Wallin et al.99 reported an increase in UES pressure following one minute of intra-esophageal acid infusion in humans using the pull-through technique. However, this increase was not maintained four minutes later. Gerhardt et al.,59 using the pull-through technique, demonstrated that the UES pressure augmentation occurs in response to volume distention and that this response is further enhanced by HCl and is not dependent on osmolarity of the infusate.Vakil et al.,60 using a sleeve sensor, monitored the UES pressure continuously during acid reflux events and compared the mean UES pressure between a period of 135 seconds prior to and following reflux events and did not find a significant reflux-induced UES pressure augmentation. This study corroborated an earlier report by Kahrilas et al. who also did not find a UES pressure increase
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一般社団法人交通科学研究会：トップページ
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Hot Sale Medical Portable 5 L Oxygen-concentrator Oxygen ...
Hot Sale Medical Portable 5 L Oxygen-concentrator Oxygen Generator For Home And Hospital Ues , Find Complete Details about Hot Sale Medical Portable 5 L Oxygen-concentrator Oxygen Generator For Home And Hospital Ues,5 L Oxygen Concentrator,Portable Oxygen-concentrator Machine,Medical Oxygen Concentrator from Physical Therapy Equipments Supplier or …Hot Sale Medical Portable 5 L Oxygen-concentrator Oxygen Generator For Home And Hospital Ues - Buy 5 L Oxygen Concentrator,Portable Oxygen-concentrator Machine,Medical Oxygen Concentrator Product on Alibaba.com.
Keyword: Hot Sale Medical Portable 5 L Oxygen-concentrator Oxygen Generator For Home And Hospital Ues - Buy 5 L Oxygen Concentrator, Portable Oxygen-concentrator Machine, Medical Oxygen Concentrator Product on Alibaba.com
From: www.alibaba.com
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From: www.apenasdetalhes.com
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Physics I & II year Practical Questions 2
2 BOARD OF INTERMEDIATE EDUCATION, TS., HYDERABAD PHYSICS PRACTICAL Model Question Paper with Scheme of valuation (For the Academic Year 2020-21) Time: 3Hrs..
From: tsbie.cgg.gov.in
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From: www.koreascience.or.kr
A human model of restricted upper esophageal sphincter ...
May 19, 2016 · Application of the external cricoid pressure increased the length of the UES-HPZ from 2.5 ± 0.2 cm without the band to 3.1 ± 0.2, 3.5 ± 0.1, and 3.7 ± 0.1 cm for 20, 30, and 40 mmHg cricoid restrictive pressure, respectively (P < 0.05 at …Europe PMC is an archive of life sciences journal literature..
Keyword: Europe PMC, Europe PubMed Central, open access, research articles, journal articles, abstracts, full text, literature search, clinical guidelines, biological patents, life sciences, bioinformatics, biomedical research, citation search, biomedical journals, ORCIDs, text mining, citation networks, REST APIs
From: europepmc.org
Frontiers | Upper esophageal sphincter mechanical states ...
The swallowing muscles that influence upper esophageal sphincter (UES) opening are centrally controlled and modulated by sensory information. Activation of neural inputs to these muscles, the intrinsic cricopharyngeus muscle and extrinsic suprahyoid muscles, results in their contraction or relaxation, which changes the diameter of the lumen, alters the intraluminal pressure and ultimately inhibits or promotes flow of content. This relationship that exists between the changes in diameter and concurrent changes in intraluminal pressure has been used previously to calculate the “mechanical states” of the muscle; that is when the muscles are passively or actively, relaxing or contracting. Diseases that alter the neural pathways to these muscles can result in weakening the muscle contractility and/or decreasing the muscle compliance, all of which can cause dysphagia. Detecting these changes in the mechanical state of the muscle is difficult and as the current interpretation of UES motility is based largely upon pressure measurement (manometry), subtle changes in the muscle function during swallow can be missed. We hypothesized that quantification of mechanical states of the UES and the pressure-diameter properties that define them, would allow objective characterization of the mechanisms that govern the timing and extent of UES opening during swallowing. To achieve this we initially analyzed swallows captured by simultaneous videofluoroscopy and UES pressure with impedance reco....
Keyword: Swallow, dysphagia, Pressure, impedance, Neural Pathways, upper esophageal sphincter, Cricopharyngeus muscle, suprahyoid muscles.
From: www.frontiersin.org
The swallowing muscles that influence upper esophageal sphincter (UES) opening are centrally controlled and modulated by sensory information. Activation of neural inputs to these muscles, the intrinsic cricopharyngeus muscle and extrinsic suprahyoid muscles, results in their contraction or relaxation, which changes the diameter of the lumen, alters the intraluminal pressure and ultimately inhibits or promotes flow of content. This relationship that exists between the changes in diameter and concurrent changes in intraluminal pressure has been used previously to calculate the “mechanical states” of the muscle; that is when the muscles are passively or actively, relaxing or contracting. Diseases that alter the neural pathways to these muscles can result in weakening the muscle contractility and/or decreasing the muscle compliance, all of which can cause dysphagia. Detecting these changes in the mechanical state of the muscle is difficult and as the current interpretation of UES motility is based largely upon pressure measurement (manometry), subtle changes in the muscle function during swallow can be missed. We hypothesized that quantification of mechanical states of the UES and the pressure-diameter properties that define them, would allow objective characterization of the mechanisms that govern the timing and extent of UES opening during swallowing. To achieve this we initially analyzed swallows captured by simultaneous videofluoroscopy and UES pressure with impedance recording. From these data we demonstrated that intraluminal impedance measurements could be used to determine changes in the internal diameter of the lumen when compared to videofluoroscopy. Then using a database of pressure-impedance studies, recorded from young and aged healthy controls and patients with motor neuron disease, we calculated the UES mechanical states in relation to a standardized swallowed bolus volume, normal aging and dysphagia pathology. Our results indicated that eight different mechanical states were almost always seen during healthy swallowing and some of these calculated changes in muscle function were consistent with the known neurally dependent phasic discharge patterns of cricopharyngeus muscle activity during swallowing. Clearly defined changes in the mechanical states were observed in motor neuron disease when compared to age matched healthy controls. Our data indicate that mechanical state predictions were simple to apply and revealed patterns consistent with the known neural inputs activating the different muscles during swallowing.
Introduction
The upper esophageal sphincter (UES) is a region of high pressure located at the juncture between the pharynx and esophagus. The UES is a gate-keeper which prevents breathed-in air from entering the esophagus and guards against
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UNIVERSITY OF CENTRAL FLORIDA UES INFO UTL 001 …
UES INFO UTL 001 Rev 5 - 11/14/2018 Rate Information Page 1 of 13 UES INFO UTL 001 – Rate Information . Utility services at the University of Central Florida are accounted for as an auxiliary operation. The Department of Utilities and Energy Services (UES) receives payment from all utility users to cover the cost of services consumed..
From: www.energy.ucf.edu
Nutcracker upper esophageal sphincter - Herbella - Annals ...
Mar 14, 2019 · UES basal pressure was 235±89 (range 190-699) mmHg. Residual pressure was normal in all patients. Mean DeMeester score was 13.0±16 range 0–29. Ten (32%) patients had pathologic reflux with equal distribution of reflux pattern (50% supine vs. 50% upright). Six (19%) had extra-esophageal symptoms (throat secretion n=2, throat clearing n=2 ...Nutcracker upper esophageal sphincter.
From: aoe.amegroups.com
Introduction
Some specific manometric patterns characterize well-defined motility disorders of the esophageal body (1). These named motility disorders changed in nomenclature and definition when high-resolution manometry replaced conventional manometry and the Chicago classification was introduced. Conventional manometry defined hypertensive peristalsis as a “nutcracker esophagus” (2) that corresponds to the “jackhammer esophagus” described in the high resolution classification (3). It is elusive whether a similar condition as the nutcracker esophagus exists in the upper esophageal sphincter (UES).
The UES was neglected during the era of conventional manometry. Some inherent technical limitations of the past technology due to artifacts of movement and the low frequency response of water perfused systems precluded an accurate study of the UES (4). The analysis of the relaxation of the sphincter and coordination with pharyngeal contraction and relaxation was certainly jeopardized by these limitations. UES basal pressure was probably the most reliable parameter measured by conventional manometry.
This study aims to evaluate the prevalence and characteristics of patients with nutcracker UES.
Methods
Population
We retrospectively reviewed 1,000 consecutive unselected esophageal function tests. Patients with previous foregut surgery were excluded from the study.
Esophageal function tests
All patients underwent esophageal manometry (Multiplex, 8-channels, water-perfused, Alacer Biomedica, Sao Paulo) to evaluate esophageal motility and to locate the upper border of the lower esophageal sphincter (LES). Position, pressure, length, and relaxation of the LES were measured using the station pull through technique, with 1-cm increments. Esophageal body wave’s amplitudes were recorded 3, 8, 13, and 18 cm above the upper border of the LES by giving 10 swallows of 5 mL of water at 30-second intervals. Position, pressure and relaxation of the UES were recorded. UES basal pressure was measured at the point of highest pressure at least 2 seconds prior or after swallows to avoid pre and post relaxation increases. UES residual pressure <1 mmHg zeroed at atmospheric pressure was considered
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一般社団法人交通科学研究会：トップページ
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From: kokaken.or.jp
Mercedes-Benz GLB 200 4 Matic test sürüşü | 4 çekere ...
Bu kez Mercedes'in fiyat-performans ürünü olarak nam salan yedi koltuklu SUV modeli GLB'yi kullanıyoruz. Ancak konuğumuz ailenin 1.33 litrelik turbo motorlu ....
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The Esophageal Manometry with Gas-perfused Catheters ...
Jun 14, 2018 · The total length of the esophagus, i.e. esophageal body and both UES and LES, amounted on average 21.9 ± 2.69 cm (n=1521) and was correlated with the body height and weakly correlated with BMI in both male and female. In 24-hour pH monitoring, the DeMeester score was pathological (> 14.7) in 41.8% (hiatal hernia 61.6%, achalasia 23.1%). In ...Europe PMC is an archive of life sciences journal literature..
Keyword: Europe PMC, Europe PubMed Central, open access, research articles, journal articles, abstracts, full text, literature search, clinical guidelines, biological patents, life sciences, bioinformatics, biomedical research, citation search, biomedical journals, ORCIDs, text mining, citation networks, REST APIs
From: europepmc.org
Upper esophageal sphincter tone and reactivity to stress ...
Anxiety and abnormal upper esophageal sphincter function have been ascribed ill- defined roles in the etiology of globus sensation. In this study, we examined the psychological profile and effect of acute mental stress (dichotic listening task) on UES tone in seven patients reporting to the clinic with globus sensation and 13 healthy controls. Alterations in heart rate, blood pressure ...Anxiety and abnormal upper esophageal sphincter function have been ascribed ill- defined roles in the etiology of globus sensation. In this study, we exami.
From: link.springer.com
Upper esophageal sphincter impedance as a marker of ...
May 01, 2012 · Patients with <10 mm, 10–14 mm (normal), and ≥15 mm UES diameter had average UES nadir impedances of 498 ± 39 Ohms, 369 ± 31 Ohms, and 293 ± 17 Ohms, respectively (ANOVA P = 0.005). A higher swallow risk index, indicative of poor pharyngeal swallow function, was associated with narrower UES diameter and higher UES nadir ….
From: journals.physiology.org
PRIME PubMed | A human model of restricted upper ...
Application of external cricoid pressure increased the length of the UES high pressure zone from 2.5 ± 0.2 to 3.1 ± 0.2, 3.5 ± 0.1, and 3.7 ± 0.1 cm for 20, 30, and 40 mmHg cricoid pressure, respectively (P < 0.05). External cricoid pressure had no …PubMed journal article: A human model of restricted upper esophageal sphincter opening and its pharyngeal and UES deglutitive pressure phenomena. Download Prime PubMed App to iPhone, iPad, or Android.
From: neuro.unboundmedicine.com
Citation
Jiao, Hongmei, et al. "A Human Model of Restricted Upper Esophageal Sphincter Opening and Its Pharyngeal and UES Deglutitive Pressure Phenomena." American Journal of Physiology. Gastrointestinal and Liver Physiology, vol. 311, no. 1, 2016, pp. G84-90.Jiao H, Mei L, Sharma T, et al. A human model of restricted upper esophageal sphincter opening and its pharyngeal and UES deglutitive pressure phenomena. Am J Physiol Gastrointest Liver Physiol. 2016;311(1):G84-90.Jiao, H., Mei, L., Sharma, T., Kern, M., Sanvanson, P., & Shaker, R. (2016). A human model of restricted upper esophageal sphincter opening and its pharyngeal and UES deglutitive pressure phenomena. American Journal of Physiology. Gastrointestinal and Liver Physiology, 311(1), G84-90. https://doi.org/10.1152/ajpgi.00145.2016Jiao H, et al. A Human Model of Restricted Upper Esophageal Sphincter Opening and Its Pharyngeal and UES Deglutitive Pressure Phenomena. Am J Physiol Gastrointest Liver Physiol. 2016 07 1;311(1):G84-90. PubMed PMID: 27198193.
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Pharyngo‐Esophageal Modulatory Swallow Responses to Bolus ...
Dec 20, 2021 · INTRODUCTION. Oropharyngeal swallowing is a highly complex process requiring adequate neuro-regulation and modulation to safely transfer the bolus from the mouth to the esophagus. 1 Afferent sensory information from the mouth and oropharynx is important for accommodation of the swallow motor response to a specific bolus. 2-7 Bolus properties like ….
From: onlinelibrary.wiley.com
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