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Anti-hypertensive and angiotensin-converting enzyme ...
Results: Our data showed that AME inhibited ACE activities in a dose-dependent manner, with an IC 50 of 1.85 ± 0.01 μg/ml. In comparison with mock, oral administration of AME reduced systolic blood pressure (SBP) levels in SHRs, and the level of SBP was decreased by 22.33 ± 3.61 mmHg at 200 mg/kg AME.the ACE inhibitory effect of AM and the presence of ACE inhibitory phytopeptide in AME supported the ethnomedical use of AM on hypertension..
Keyword: pmid:32119952, doi:10.1016/j.jep.2020.112724, Jing-Shan Wu, Jung-Miao Li, Tin-Yun Ho, Angiotensin-Converting Enzyme Inhibitors / pharmacology, Angiotensin-Converting Enzyme Inhibitors / therapeutic use*, Animals, Antihypertensive Agents / pharmacology, Antihypertensive Agents / therapeutic use*, Astragalus propinquus, Blood Pressure / drug effects, Drugs, Chinese Herbal / pharmacology, Drugs, Chinese Herbal / therapeutic use*, Hypertension / drug therapy*, Male, Mice, Inbred BALB C, Molecular Docking Simulation, Peptides / pharmacology, Peptides / therapeutic use*, Peptidyl-Dipeptidase A / metabolism, Rats, Inbred SHR, PubMed Abstract, NIH, NLM, NCBI, National Institutes of Health, National Center for Biotechnology Information, National Library of Medicine, MEDLINE
From: pubmed.ncbi.nlm.nih.gov
Ethnopharmacological relevance:
Hypertension is one of the common chronic health problems in the world. Astragalus membranaceus root (AM), also known as Huangqi, is a popular medicinal herb traditionally used to reinforce vital energy and modulate hypertension.
Aim of the study:
This study was to reveal the anti-hypertensive activities and mechanisms of AM in spontaneously hypertensive rats (SHRs). Moreover, the presence of bioactive components in AM was further identified.
Materials and methods:
We analyzed the effects of aqueous extract of AM (AME) on the regulation of blood pressure and angiotensin converting enzyme (ACE), the major target of anti-hypertensive drugs. Proteomic, bioinformatics, and docking analyses were performed to identify the anti-hypertensive bioactive peptides in AME.
Results:
Our data showed that AME inhibited ACE activities in a dose-dependent manner, with an IC50 of 1.85 ± 0.01 μg/ml. In comparison with mock, oral administration of AME reduced systolic blood pressure (SBP) levels in SHRs, and the level of SBP was decreased by 22.33 ± 3.61 mmHg at 200 mg/kg AME. Proteomic analysis identified that an abundant 152-amino-acid putative protein kinase fragment accounted for approximately 11.7% of protein spots in AME. AM-1 (LVPPHA), a gastrointestinal enzyme-resistant peptide cleaved from putative protein kinase fragment, inhibited ACE activities, with an IC50 value of 414.88 ± 41.88 μM. Moreover, oral administration of AM-1 significantly decreased SBP levels
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DESCRIPTION: modular incremental encoder
PART NUMBER: AME ELECTRICAL SPECIFICATIONS output waveform Square wave output signals A, B phase output voltage H: ≥ 85% Vcc L: ≤ 0.3 V current consumption ≤ 25 mA output phase difference 90° ± 45° supply voltage 5 V dc output resolution (ppr) 100, 200, 256, 360, 400, 500, 512, 1000, 1024.
From: media.digikey.com
AME41-1.2Shunt Voltage Reference
AME 8 AME41-1.2 Shunt Bandgap Voltage Reference Rev.H.01 Package Carrier Width (W) Pitch (P) Part Per Full Reel Reel Size SOT-23 8.0±0.1 mm 4.0±0.1 mm 3000pcs 180±1 mm Carrier Tape, Number of Components Per Reel and Reel Size SOT-23 n Tape and Reel Dimension n Date Code Rule Year A A A W W xxx0 A A A W W xxx1 A A A W W xxx2 A A A W W xxx3 A ....
From: www.ame.com.tw
Assessment of left ventricular myocardial work in Turner ...
Introduction. Turner syndrome (TS) is an X-chromosomal disease that occurs approximately in one out of 2,500 to 3,000 female newborns ().Girls and women with TS have an increased cardiovascular morbidity (): congenital heart defects such as the bicuspid aortic valve or the coarctation of the aorta are frequently seen among this cohort ().TS is also associated with …Assessment of left ventricular myocardial work in Turner syndrome patients: insights from the novel non-invasive pressure-strain loop analysis method.
From: qims.amegroups.com
Introduction
Turner syndrome (TS) is an X-chromosomal disease that occurs approximately in one out of 2,500 to 3,000 female newborns (1).
Girls and women with TS have an increased cardiovascular morbidity (2): congenital heart defects such as the bicuspid aortic valve or the coarctation of the aorta are frequently seen among this cohort (3). TS is also associated with multiple cardiovascular and cardiometabolic risk factors such as diabetes, lipid anomalies, arterial hypertension and excess weight (4). In addition, arterial stiffness, a predictive cardiovascular risk marker (5), has been shown to be elevated in TS patients (6-9).
The accumulation of the above-mentioned risk factors, which may also promote the arterial stiffening process of the small and major vessels, is assumed to increase left ventricular afterload and thus impair left ventricular function. Studies could demonstrate that TS patients display lower left ventricular function and higher left ventricular mass (10,11). However, in a recent study of our group, the previously described left ventricular dysfunction could not be confirmed through two-dimensional speckle tracking echocardiography (2DSTE) (6).
Recently, a new echocardiographic method has been introduced allowing the measurement of myocardial work and myocardial efficiency through left ventricular pressure-strain loops (12,13).
The aim of this study was to investigate whether alterations in myocardial work and work efficiency can be found in TS patients through left ventricular pressure-strain loop analysis (PSL) in comparison to conventional left ventricular global strain assessment.
Methods
Ethical statement
This study was a retrospective analysis of prospectively collected data and was approved by the Ethics Committee of the Arztekammer des Saarlandes (State Chamber of Physicians of the German federal state of Saarland), Faktoreistrase 4, 66111 Saarbrucken, Germany, on March 23rd, 2018; approval statement
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Gantry CNC Flame & Plasma Cutting Beveling Machine for ±45 ...
Gantry CNC plasma beveling cutting machine for steel plate and pressure vessel etc The machine may be customized by your real application/cutting process req....
From: www.youtube.com
Passive and active exercises are similarly effective in ...
Sep 30, 2015 · The average age of the exercisers (68.0±5.4 yr) in their study was much lower than those of the participants in the current study (PME 83.7±4.2 yr; AME 86.0±4.2 yr). Yamauchi et al. 20 ) found an 18% improvement in AC score and 6% improvement in CS score following a 26-min home-based exercise program performed 3 days/week for 12 weeks.[Purpose] The aim of this study was to compare the efficacy of passive motion exercise
and active motion exercise on functional fitness in elderly nursing home residents.
[Subjects and Methods] Twenty-three (female 22 and male 1) nursing home residents
(84.8±4.3 ....
From: www.ncbi.nlm.nih.gov
INTRODUCTION
It is well documented that an inactive lifestyle, such as bed rest, in otherwise healthy
individuals is associated with decreased physical function exacerbated by changes in body
composition, that is, decreased muscle mass and increased fat mass1). A nursing home-based lifestyle is often sedentary, and it
has been reported that frail older women residing in a nursing home experienced a
significant progressive loss of muscle mass2).On the other hand, research over the past two decades clearly shows that regular exercise,
that is, active motion exercise (AME), is effective for maintaining and promoting health,
physical fitness, and functional independence in older adults, especially in terms of
endurance, muscular strength, flexibility, and balance3,4,5). However, there are many older adults who have limitations in
performing active exercises, especially weight-bearing exercises due to orthopedic
conditions, poor musculoskeletal conditions, excess adiposity, poor balance, or simply
age-associated sarcopenia6,7,8). Passive motion
exercise (PME) may be an alternative mode of exercise for those elderly who cannot perform
AME.Machine-based PME was found to be beneficial in frail elderly users of a day care
service9) as well as in
community-dwelling chronic stroke patients with spastic paralysis10). However, little information is available about PME in
nursing home residents, and its efficacy has not been compared with that of AME. Therefore,
the purpose of the current study was to compare the efficacy of PME with that of AME in a
group of nursing home-dwelling elderly people.
SUBJECTS AND METHODS
In response to a public call for participation (leaflets and oral) through proper channels,
23 residents (mean age 85.3 yr; 80 to 98 yr, 22 female and 1 male) of a nursing home in
Yokkaichi City, Mie Prefecture, Japan, volunteered to participate in this study. The average
nursing home residence period for these people was 8.2 years (1.9 years to 18.4 years). The
participants () were then divided into a PME group and an AME group. The nursing home where
the participants were residing assists only in instrumental activities of daily living
(ADL)11), and all participants were able
to walk indoors by themselves. No assistance was needed for these people while eating,
dressing, or taking a bath. However, assistance was needed in preparing food, preparing a
bathtub, preparing a shower room etc. None of them were suffering from uncontrolled
hypertension, congestive heart failure, untreated ischemic heart disease, or untreated
arrhythmia. None had any restrictions advised by their attending physician with regard to
physical exercise performance.
Table 1.
PME (n=12)AME (n=11)Age (yrs)83.7±4.286.0±4.2Height (cm)149.2±6.5149.7±4.0Body mass (kg)49.0±7.752.4±6.1BMI (kg/m2)22.0±2.523.4±2.5Arm Curl (times/30 sec)16.0±4.017.6±4.2Chair Stand (times/30 sec)12.3±3.513.0±2.5Up and Go (sec)10.3±7.28.2±1.9Sit and Reach (cm)4.0±6.05.2±12.3Back Scratch (cm)−12.8±12.1−10.4±11.6Functional Reach (cm)19.3±6.515.9±5.412-min walk distance (m)505±209646±106Open in a separate windowThe ethics
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Hatsune Miku - Sakura no Ame (Project DIVA F 2nd) sub ...
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From: www.youtube.com
ADDITIVELY MANUFACTURED ELECTRONICS (AME)
Maximum AME dimensions 160 x 160 x 3 mm (x, y, z) Overall AME thickness 0.7 – 3.0 mm, tolerance of less than ± 5% Signal / plane layer thickness* Min: 17 um, 6 um steps up to 101 um. Prepreg between signal layers / signal to plane layer Min: 25um ± 5% , ….
From: www.nano-di.com
A Multiple-step Overall Kinetic Mechanism for the ...
c = O.4O±O.O3 for VII; , x 14.70±2.00 = E = 50,0O0±500O, a = 0.90±0.08, b = 1.18±0.10, and , S — 7.93 exp(—2.48^), where
From: ronney.usc.edu
HOUSE BILL NO. 655 IN THE HOUSE
odm±~±~~eri~g--th±~--enepte~,--exe±tl3i~e--of-the-pcymen~~-~f ~etire~e~t-a~~owcnee~-8~0-e~her-beneftt~,-may-be--~e±d--f~om the-£~ndo ti!t In addition to the contributions elsewhere provided in this chapter, on Jar.uary i of each year each employer shall contribute on behalf of each member then in.
From: courts.mt.gov
Acompáñame - Alicia Villarreal - Lyrics
Acompañame
Porque puede suceder
Acompañame
Que me llegues a querer
Pon tu mano, sobre mi mano
Y a tu lado, todo el mundo correre
Ven conmigo
Cierra los ojos
Y en silencio
Sin palabras
Yo mil cosas te dire
Acompañame
Que tu amor es mi canción
From: www.songlyrics.com
Bad selectionCannot annotate a non-flat selection. Make sure your selection
starts and ends within the same node.
(example of bad selection): This is bold
text and this is normal text.
(example of good selection): This is bold
text and this is normal text.
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MOLDINO - The Edge To Innovation -｜株式会社MOLDINO
~_C»t 0`o 1 ã Q ² Í^d `h{Ô 1 9 £ C \b _Pw 9 £ ÿn` `h{~ Employs a carbide substrate with high toughness and the new "AJ Coating" to improve wear resistance and chipping resistance when machining stainless-steel materials. ~ Employs AJ Coating with excellent welding resistance to reduce the welding to work material that occurs when.
From: www.moldino.com
NTC Thermistors, Mini Epoxy PVC Twin Insulated Leads
Tolerance on R25-value ± 1.0 to ± 5.0 % B25/85-value 3435 to 4190 K Tolerance on B25/85 ± 0.5 to ± 1.5 % Operating temperature range at zero dissipation-40 to 105 °C Maximum power dissipation at 55 °C 100 mW Accuracy of temperature measurement (for 1 % types) ± 0.5 between 0 and 40 ± 1.0 between -40 and 80 °C Dissipation factor G (in ....
From: www3.nd.edu
Inter Research » AME » v28 » n2 » p117-129
The number of suspended bacteria was always highest at the landfill site (4.0 ± 4.2 [standard deviation, SD] x 10 6 cells cm-3), i.e. on average 16 times higher than in the well water (2.5 ± 3.0 x 10 5 cells cm-3) and 96 times higher than in the pristine groundwater (4.1 ± 1.3 x 10 4 cells cm-3)..
From: www.int-res.com
BULLETIN OF THE ALLYN MUSEUM
1.362±0.0632 1.362± 4.637% SIGNIFICANCE OF R (MEAN VALUE) DIFFERENCES - t TEST ~ ~ 9 9 n 48 48 t 6.08 10.01 p < 0.0001 < 0.0001 p < .0.01 is highly significant. 6 Colias scudderi Reakirt 1865 Figs. 4-28 Colias scudderii Reakirt, 1865: 217-218. TL - Rocky Mountains, Colorado Territory, Holotype-Lost. ....
From: www.floridamuseum.ufl.edu
Cytoprotective effect of amniotic membrane extracts on ...
Background: The goal was to explore the protective effect and potential mechanism of amniotic membrane extracts (AME) on the ocular surface exposed to benzalkonium chloride (BAC). Methods: The human corneal epithelial cell (HCEC) line SD-HCEC1s was cultured in 5 groups: normal control (NC), NC + AME, BAC, BAC + NC, and BAC + AME.Cell viability analysis, flow …Cytoprotective effect of amniotic membrane extracts on human corneal epithelial cells exposed to benzalkonium chloride in vitro.
From: aes.amegroups.com
Introduction
Dry eye disease (DED) is a multifactorial disease of the ocular surface characterized by a loss of homeostasis of the tear film, and accompanied by ocular symptoms, in which tear film instability and hyperosmolarity, ocular surface inflammation and damage, and neurosensory abnormalities play etiological roles (1). Ocular irritation, stinging and foreign body sensation are symptoms frequently reported by patients which are exacerbated by substance such as benzalkonium chloride (BAC) (2).
Most of eye drops contain preservatives to prevent potential contamination, and the most common preservative used is BAC, which is present in eye drops generally ranges from 0.004% to 0.02% (3). BAC is cytotoxic to bacteria and to ocular surface epithelial cells. Therefore, there are a number of reports on the development of ocular surface disorders (OSD) in patients treated with BAC containing eye drops. BAC may induce ocular discomfort, tear film instability, superficial structure and integrity impairment, conjunctival inflammation, subconjunctival fibrosis, and epithelial apoptosis (2,4-8). The toxicity of BAC on cultivated corneal and conjunctival cells have been evaluated in many different species. It induces cytoplasmic damage and apoptosis, and induce DNA strand-breakage and mitochondrial dysfunction (4). BAC has been employed to investigate the pathogenesis of DED in animal models (9). In rabbits, topically applied 0.1% BAC twice daily over 4–14 days results in the development of DED (10,11). In mice, 0.2% BAC applied twice daily triggers clinical signs of DED including loss of conjunctival goblet cells (GCs), increased fluorescein staining, and corneal irregularity (5,12-14).
Amniotic membrane (AM) is avascular and a rich source of biologically active factors with low immunogenicity and as such, promotes healing and acts as an effective material for wound dressing. AME supports epithelialization and exhibits anti-fibrotic, anti-inflammatory, anti-angiogenic and anti-microbial features (5). In ophthalmology, AM and amniotic membrane extract (AME) are widely used for ocular surface reconstruction, including the treatment of persistent epithelial defects and non-healing corneal ulcers, corneal perforations and descemetoceles, bullous keratopathy, as well as corneal disorders with associated limbal stem cell deficiency, pterygium, conjunctival reconstruction, corneoscleral melts and perforations, and glaucoma surgeries (15). Compared to AM, AME can be conveniently applied to the ocular surface without the risk of suture-related complications of amniotic membrane transplantation (AMT) (5). Boiled
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Prediction of AME, AMEn, AMEs (kcal/kg, DM), and ...
AME aligns more closely with the actual energy levels of feed ingredients likely available to growing birds, which should be used for poultry feed formulations instead of ….
From: researchgate.net
Association between blood urea nitrogen and 30-day ...
Introduction. Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Severe sepsis and septic shock affect millions of people around the world each year, and more than a quarter of these patients die ().The mortality rate of septic patients hospitalized in intensive care unit (ICU) is as high as 41.9% ().Association between blood urea nitrogen and 30-day mortality in patients with sepsis: a retrospective analysis.
From: apm.amegroups.com
Introduction
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Severe sepsis and septic shock affect millions of people around the world each year, and more than a quarter of these patients die (1). The mortality rate of septic patients hospitalized in intensive care unit (ICU) is as high as 41.9% (2). Death-risk stratification in septic patients enables early identification of patients at high risk of death and facilitates rational allocation of medical resources to improve outcomes. Scoring tools such as Acute Physiology and Chronic Health Evaluation (APACHE) can be used for risk stratification in septic patients, but its implementation is relatively cumbersome and can be easily influenced by some highly variable parameters such as heart rate and respiration (3). Therefore, there is a need to find clinically common and practicable markers for the rapid death-risk stratification of septic patients, which is also an important research direction of the Surviving Sepsis Campaign (4).
Blood urea nitrogen (BUN) is the main end product of protein metabolism in the human body and is excreted mainly by the kidneys. BUN level will increase when there is excessive protein breakdown or when the glomerular filtration rate decreases. Thus, BUN level can reflect protein catabolism in the human body (5) and is also a marker of renal impairment. The rate of protein catabolism increases significantly in patients with sepsis (6), and sepsis is often complicated with acute renal injury (7). These factors can lead to an increase in BUN levels in patients with sepsis. Meanwhile, the BUN test is simple and common in clinical laboratories.
Previous studies have suggested that elevated BUN level may independently predict mortality in critically ill patients (8,9); however, these studies had small sample sizes, and a large-sample study of 30-day mortality risk stratification using BUN level in patients with sepsis has yet to be performed. By using the Medical Information Mart for Intensive Care III (MIMIC-III) database, we performed this real-world study with a large sample size to investigate the relationship between BUN level and 30-day mortality in patients with sepsis. We present the following article in accordance with the STROBE reporting checklist (available at https://dx.doi.org/10.21037/apm-21-2937).
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